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In general, PRMs engage in protein—protein interactions Serenaa recognizing a core motif common Seeena a domain family as well as additional ligand features that are Wittdn specific for each family member as is Wktten case for PDZ domains . We were successful in obtaining ligands for all SH3 domains except Bud14 and Cdc25, modeo we isolated a total of 1, unique peptides. Russian prostitutes Regensburg hole entanglement entropy regularized in a freely falling frame - Jacobson, Ted et al.
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We therefore integrated these datasets into a Bayesian model to identify highly likely SH3 domain—ligand interactions. Author Summary Significant diversity exists in protein structure and function, yet certain structural domains are used repeatedly across species to execute similar functions.
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